Blocking IL-11 Gene Reduces Inflammation So Mice Live 24% Longer and Healthier

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan- Nature Female Il11-deleted mice are protected from age-associated obesity, frailty, and metabolic decline. Male mice lives 22.5% longer and female mice 25% longer. The effects were similar to rapamycin but had less negative effects on liver and other organs when rapamycin is used for extended times. ...

The Only Version of Return of the King Worth Watching Missing From Max After Streaming Bug

Screenshot: Warner Bros. Bad news for Max subscribers who’ve made re-watching The Lord of the Rings extended editions an annual New Year tradition: the third film in the trilogy, The Return of the King — which just celebrated its 20th anniversary! —is only available to stream in its theatrical version. No ancient evil is to blame, thankfully; it’s an unspecified “tech issue,” according to a Max spokesperson who responded to a comment request from Vulture after the issue was noted by dismayed fans on Reddit . The fact that The Return of the King extended edition is merely temporarily unavailable is actually good news given Max’s track record for removing content in the past, and the explanation makes sense considering The Fellowship of the Ring and The Two Towers remain available in both their theatrical and extended editions. The Max spokesperson assured Vulture that The Return of the King extended edition will be, ah, returning soon to the service, though as of this writing i...

Unicorn Jerky Is Not Only the Perfect Name for a CBD Candy Edible, It's Also 20% Off, and Proceeds Go to The Trevor Project [Exclusive]

You Can Visit Freddy Fazbear's Pizza in Hollywood

Image: Universal Pictures Just in time for Halloween and for the release of Blumhouse and Universal Pictures’ Five Nights at Freddy ’s fans can visit a pop-up location of the fictional franchise from the game and film. That’s right, a Freddy Fazbear’s Pizza has mysteriously appeared in Hollywood. Like in the game and upcoming film, it’s a run-down spot that’s been closed down due to some mysterious activity within. Unfortunately, you can’t actually go in unless you’re hired as a security guard (kidding)—it’s just a facade for photo-ops you can visit. Check out the video captured by deadboifilms on TikTok below at the location on Sunset Blvd in Hollywood (near the Chateau Marmont Hotel). If you want to encounter the animatronic band of fuzzy and totally friendly creatures from the game, you’ll have to visit Universal Studios Hollywood Halloween Horror Nights, there’s a walk-through in the DreamWorks theater lobby that’s been taken over by Blumhouse which features the real Jim ...

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